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Figure 1 Samples for blood glucose concentration (A) and serum insulin concentration (C) before and 30 min, 60 min, and 120 min after glucose load were obtained and AUCs were calculated (B and D, respectively). * Compared with the Con group, P 1D. The serum insulin concentrations in the MSG and MSG-HRP groups at fasting, 30 min and 60 min after oral glucose and the AUCs of serum insulin concentrations were lower than the values obtained for the Con groups. AUC of serum insulin concentration in the MSG-HRP group was higher than in the MSG group, although without statistical significance. Insulin sensitivity Alizarin was evaluated according to ITT and the results were shown in Figure 2. The decreased rate of blood glucose Fulvestrant was smaller in the MSG group compared with the Con group at 15 min after insulin injection (P were labeled by insulin and glucagon antibodies, respectively (Figures 3, ?,4).4). To quantify the changes in ��-cell and ��-cell masses, the ratios of respective stained area of insulin and glucagon to whole islet area were calculated, and the results are shown in Figure 3D and Figure 4D. MSG rats treated with HRP increased SB203580 cost ��-cell mass compared with the MSG group (P