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The study was approved by the Tehran University Ethics Committee, and written consent was obtained from all subjects prior to enrollment. This study was conducted on 35-70 years old patients with diabetes and hypertension Type 2 referred to Firoozgar Hospital from March 2011 to February 2012. Sixty-eight subjects [4 in dark chocolate group (DCG) and 34 in white Resminostat chocolate group (WCG)] with established Type 2 diabetes (age for DCG = 58.71 �� 9.07 and for WCG = 57.17�� 7.86 years) were enrolled by blocked randomization method. During the study 2 cases because of insulin use in DCG and 6 cases from WCG because of insulin use (n = 2) and other supplement consumption (n = 4) were excluded. Whom 60 patients (32 in DCG and 28 in WCG) completed the study. The mean diagnosis duration of diabetes was (mean �� standard deviation for DCG = 7.46 �� 4.62 and for WCG = 7.92 �� 3.92) months. Inclusion criteria were diagnosis of Type 2 diabetes based on the World Health Organization guidelines [fasting blood sugar (FBS) > 126 mg/dl or 2h BS > 200 mg/dl]14 and systolic blood pressure �� 140 and diastolic blood pressure �� 90 .15 Exclusion criteria included click here hemoglobin A1c (HbA1c) > 9.0%, treatment with insulin, any change in use of medication in the previous 2 months, having any kind of special diets such as vegetarian, lactation, pregnancy, congestive heart failure, malignancies, chronic kidney disease, severe cardiac arrhythmias and inflammation. All participants were either life-long nonsmokers or reported smoking abstinence of at least 5 years before study inclusion. All of the subject��s chronic medications such as lipid reducing and blood pressure reducing drugs were maintained at stable doses for at least 2 months prior to the start of the study. The subjects were given chocolate bars containing either dark chocolate or white chocolate in the same package by blind person. The chocolates delivered as a monthly manner and compliance were assessed by asking for how many of the chocolate bars were used. Individual��s adherence after 8 weeks intervention Staurosporine ic50 was determined by total chocolate number to consumed chocolate. The individuals with