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, 2Respiratory Medicine, National Hospital Organization Nanao Hospital, Nanao, Japan, 3Respiratory Medicine, Kanazawa University Hospital, Kanazawa, Japan Background?Sinobronchial Anticancer Compound Library syndrome is a major cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that prostanoids are key elements in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of prostacyclin in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation. Methods?The effect of beraprost, a chemically and biologically stable analogue of prostacyclin, on cough response to inhaled capsaicin was examined in 14 patients with sinobronchial syndrome in a randomized, placebo-controlled cross over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. Results?The cough threshold was significantly (p?Sitaxentan may be a novel therapeutic option for patients with sinobronchial syndrome. YOSHIHISA ISHIURA1, MASAKI FUJIMURA2, YASUTAKA SHIBA1, HIDEKO IKEDA1, NORIYUKI OHKURA3, JOHSUKE HARA3, KAZUO KASAHARA3 1Respiratory Medicine, Toyama City Hospital, Toyama, Japan., 2Respiratory Medicine, National Hospital Organization Nanao Hospital, Nanao, Japan, 3Respiratory Medicine, Kanazawa University Hospital, Kanazawa, Japan Background?Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase2, Alectinib one of the inducible isoforms of cyclooxygenase is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of cyclooxygenase2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation. Methods?The effect of etodolac, a potent cyclooxygenase2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. Results?The cough threshold was significantly (p?
