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Mean baseline ocular symptom scores were also comparable between MFNS- and placebo-treated patients in each of these three groups. These baseline scores were lower in the PAR studies and in the retrospectively analyzed SAR studies compared with the prospectively analyzed SAR data because no minimum baseline ocular symptom score was required except in the prospectively analyzed SAR studies. MFNS-treated patients experienced significantly greater reductions vs placebo in each of the three ocular symptoms evaluated in both the PAR studies and the SAR studies. In the SAR analysis, the mean differences http://www.selleckchem.com/products/Y-27632.html [95% CI] in symptom scores between MFNS-treated and placebo-treated patients were ocular tearing (?0.09 [?0.10, ?0.07]), itching (?0.10 [?0.12, ?0.08]), and redness (?0.08 check details [?0.10, ?0.6]) over 15?days of treatment (Fig.?1). Overall effect was significant for all three individual symptoms (Z?=?9.18 for tearing, Z?=?10.15 for itching, and Z?=?8.88 for redness; P?Fleroxacin both the SAR and PAR analyses, which included a total of 3132 patients, all individual ocular symptoms were reduced in patients treated with MFNS. This is particularly noteworthy in light of the fact that entry criteria for all but two of the SAR trials did not include a minimum ocular symptom score. Furthermore, the overall beneficial effect of MFNS was consistent across ocular symptoms even though there was a variable degree of heterogeneity among the SAR studies. Our findings add to the growing body of literature supporting the positive class effect of INSs, including MFNS, on ocular symptoms associated with SAR (15, 17, 18, 23�C31). Our results are consistent with findings from individual studies and pooled analyses examining MFNS for relief of allergic eye symptoms (15, 16).