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As for the combination compound lubricant, its superior performance compared to the other two lubricants is attributed to the composition (containing both PTFE and silicone) in combination with the fluidity (sufficient to allow the swift formation of a lubricating layer) of the combination compound. The observation that a combination of two types of lubricant works better than each one alone is in line with the previous work on internal lubricants such as silicone and PDMS.17 thiram It is not fully understood why the use of internal lubrication of the POM and PBT materials together with the external combination compound did not result in any further reduction in CoF (combination 11). It is hypothesized, however, that the external lubricant forms a fully continuous film by itself and that the properties of this film determine the frictional performance in both combination 10 and combination 11, essentially rendering the performance independent of the properties of the base materials. System force efficiency The theoretically calculated relationship between the dimensionless overall Erastin price efficiency in force transmission and CoF of the dose sleeve/threaded sleeve depicted in Figure 2 shows that CoF has a strong inverse influence on device performance. At a CoF >0.20, the force efficiency falls to 0, meaning that the mechanism is self-locking. At the other end, with the CoF approaching 0, the force efficiency increases beyond 1, meaning that, thanks to the gearing, the force arriving at the cartridge inside the pen is higher than the force applied on the dose button. In order to compare the expected performance of the different tested material combinations, the experimentally obtained kinetic CoF values were converted into force efficiency data of theoretical system using the inversely proportional relationship shown in Figure 2. The expected system selleck chemicals llc force efficiency values so obtained are showed for all combinations in Figure 11. The results are presented as box plots of all individual data points for each tested combination, ie, n=10��15, with median as well as maximum and minimum (whisker length) values displayed. Looking first at the median force efficiency value of the different polymer combinations with unmodified POM, it can be seen that the force efficiency drops by >50% when the PBT is replaced by PC and increases by >50% when PA12 is used instead of PBT. Looking next at the expected variability in force efficiency for each combination, indicated by the length of the whiskers in the box plot, it can be seen that the POM�CPBT combination has a variability of ��30% of the median. For the POM�CPC combination, the variability is ��100% and the minimum is