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However, the application of pharmacogenetics to the treatment of alcohol dependence is still in its infancy, with most studies based on comparatively small samples of convenience. Prospective studies of large samples are essential to advance this field. This will ensure that pharmacogenetics plays a key role in the personalized treatment of alcohol dependence by matching specific medications to individuals based on their genetic and epigenetic features, thereby enhancing treatment effects and reducing the risk of adverse events. Footnotes This research was supported, in part, by National Institute on Alcohol Abuse and Alcoholism Grant K24 AA13736 (to Henry R. Kranzler) and by the VISN4 MIRECC at the Philadelphia this website Veterans Affairs Medical Center.""In 2012, a record 21.6 million people were enrolled in U.S. colleges and universities (Hussar and Bailey, 2013). Understanding threats to students�� health and well-being is paramount. These threats include alcohol consumption, which is associated with consequences ranging from academic impairment (Pascarella et al., 2007; Porter and Pryor, 2007; Singleton and Wolfson, 2009) to assaults and fatalities (Hingson et al., 2009). Neither college student drinking nor its associated harms are new phenomena. Decades of research have documented drinking behavior and check details etiological factors and more recently identified successful strategies for reducing alcohol-related harm. Looking back at how the field has developed helps highlight the progress made as well as goals for the future. Method In recognition and celebration of the 75th anniversary of what is now the Journal of Studies on Alcohol and Drugs (JSAD), a review of college bepotastine drinking research across the various incarnations of the journal was conducted. The journal has been and continues to be instrumental in advancing this field; however, to provide a cohesive picture of how the science has advanced to its current state, it was necessary to incorporate literature from other academic publications. Given the pivotal role of the journal in advancing prevention science related to college drinking, articles were selected by consensus of the authors from a comprehensive literature search of PsycINFO on the basis of their relevance to the genesis of current best practices, beginning with seminal articles establishing the nature of and problems related to college drinking. In this report, the articles are organized according to major eras and themes.