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We did not detect any differences in pain severity and interference among the specific surgeries. According to the MPQ-SF, patients with PPP presented a 6.5 median sensory pain rating index, a 0.0 median affective pain rating index, and a 6.5 median total pain rating index. We did not find differences in pain rating indexes between surgical groups. Table 2. Persistent Postoperative Pain Severity and Interference Assessed With Brief Pain Inventory Short Form (n = 49) Regarding acute postoperative pain, the worst pain considered severe in the first 24 hours was associated with higher incidence of PPP (38.8% vs 19.8%, P = 0.01). The average pain considered moderate to severe CASK in the first 24 hours was also associated with development of PPP (40.8% vs. 23.0%, P = 0.019). Relative to surgical groups (Table 3), cholecystectomies were less associated with the development of PPP (8.3% vs. 31.1%, P = 0.021), and TKHR were more associated with it (50.0% vs. 25.5%, P = 0.028). Table 3. Persistent Postoperative Pain Among the Surgical Groups (n = 49) We were unable to detect differences for gender, age, body mass index, diabetes, and statin medication prior to surgery (Table 4). The percentage of patients with PPP was higher in those with any preoperative pain in the related area (51.4% vs. 21.5%, P prior surgery in the related area had a higher incidence of PPP (50.0% vs. 24.5%, P = 0.01). However, when we exclude patients with preoperative pain, Halofuginone there is no difference in the incidence of PPP (24.0% vs. 14.3%, P = 0.228). Patients with prior surgery in the related area had more preoperative pain when compared to those without it (26.3% vs. 7.1%, P = 0.008). Acalabrutinib datasheet Table 4. Persistent Postoperative Pain and Associated Factors (n = 49)a Average postoperative pain considered severe in the first 24 hours was associated with higher incidence of PPP, when compared to those with lower scores (71.4% vs. 26.2%, P = 0.009). Conversely, average postoperative pain considered mild in the first 24 hours was associated with lower incidence of PPP, when compared to higher scores (24.3% vs. 52.2%, P = 0.006). Incidence of PPP was higher in patients with the presence of any acute postoperative pain (37.0% vs. 18.5%, P = 0.021), even when we exclude patients with preoperative pain (32.2% vs. 11.1%, P = 0.011). Regarding QoL using EQ-5D, none of the EQ-5D dimensions presented a normal distribution (the Kolmogorov-Smirnov test was performed). Initially, EQ-5D dimension distributions were not different for patients with or without PPP, except for pain dimension (M: P = 0.24; SC: P = 0.197; UA: P = 0.149; pain: P