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6) On the other hand, cognitive deficits may also contribute to the psychopathologies underlying symptoms in schizophrenia and bipolar disorder patients. Several cross-sectional studies have indicated that these patients�� performance on neurocognitive tests is correlated with three major schizophrenic symptom types: positive, negative, or disorganized.7) In fact, Albus et al.8) reported that psychotic symptoms were the most influential variable affecting cognitive function in patients with bipolar disorder. Therefore, the aims of the present study were to describe intellectual function in patients with schizophrenia or bipolar disorder and to investigate the relationships between I-BET151 cost intellectual decline and the severity of each type of psychopathology. METHODS Participants For the present study, 51 participants with schizophrenia and 42 with bipolar disorder were recruited from the psychiatry outpatient clinic of Jeju University Hospital (Jeju, Korea) between March 2011 and March 2014. Patients were included in this study if they were diagnosed with either bipolar I or II disorder or schizophrenia according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). The exclusion criteria were a diagnosis of an intellectual disability or neurological disorder, or a significant physical health problem that could interfere with cognitive function. All patients included in this study were Oxygenase clinically stable. All 93 participants first completed the Korean Wechsler Adult Intelligence Scale (K-WAIS), and they were then divided into two groups according to the difference between their current intelligence quotient (IQ) and their estimated premorbid IQ: the severely impaired group (SIG) and mildly impaired group (MIG). SIG participants exhibited a score difference ��15 between their current IQ and estimated premorbid IQ, and the mildly impaired group had a score difference GSK2656157 cost three general areas of IQ (verbal IQ [VIQ], performance IQ [PIQ], and full-scale IQ) using six verbal subtests and five performance subtests: information, digit span, vocabulary, arithmetic, comprehension, similarities, picture completion, picture arrangement, block design, object assembly, and digit symbol. Premorbid intelligence estimates The premorbid intelligence estimates were assessed using the three subtests of the standardized K-WAIS (VIQ, PIQ, and full-scale IQ), controlling for age and education. The premorbid IQ of each patient was inferred using the index of premorbid intelligence developed by Kim.