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METHODS: In an Institutional Review Board approved study, 66 patients (mean age 60 �� 13 years, 44 men, and 22 women) undergoing routine abdomen CT on multi-detector CT (MDCT) scanners from vendors A, B, and C (�� 64 row CT scanners) (22 patients each) gave written informed consent for acquisition of an additional RD CT series. Sinogram data of RD CT was reconstructed with two vendor-specific and a vendor-neutral IRTs (A-1, A-2, A-3; B-1, B-2, B-3; and C-1, C-2, C-3) and SD CT series with filtered back projection. Subjective image evaluation was performed by two radiologists for each SD and RD CT series LX4211 ic50 blinded and independently. All RD CT series (198) were assessed first followed by SD CT series (66). Objective image noise was measured for SD and RD CT series. Data were analyzed by Wilcoxon signed rank, kappa, and analysis of variance tests. RESULTS: There were 13/50, 18/57 and 9/40 missed lesions (size 2-7 mm) on RD CT for vendor A, B, and C, respectively. Missed lesions includes liver cysts, kidney cysts and stone, gall stone, fatty liver, and pancreatitis. There were also 5, 4, and 4 pseudo lesions (size 2-3 mm) on RD CT for vendor A, B, and C, respectively. Lesions conspicuity was ALK sufficient for clinical diagnostic performance for 6/24 (RD-A-1), 10/24 (RD-A-2), and 7/24 (RD-A-3) lesions for vendor A; 5/26 (RD-B-1), 6/26 (RD-B-2), and 7/26 (RD-B-3) lesions for vendor B; and 4/20 (RD-C-1) 6/20 (RD-C-2), and 10/20 (RD-C-3) lesions for vendor C (P = 0.9). Mean objective image noise in liver was significantly lower for RD A-1 compared to both RD A-2 and RD A-3 images (P RG-6016 in vitro dose index volume 1.3 mGy is not sufficient to retain clinical diagnostic performance. Keywords: Adult, Computed tomographic imaging, Abdomen, Radiation dose Core tip: We assessed the performance of abdominal computed tomography (CT) acquired at sub-milli-Sievert radiation dose to the standard of care CT. A total of 66 subjects were scanned on three different multi-detector CT scanners at sub-milli-Sievert radiation dose [or CT dose index volume (CTDIvol) of 1.3 mGy]. Images were reconstructed with vendor-specific and vendor-neutral iterative reconstruction techniques (IRTs). We compared the clinical diagnostic performance of vendor specific and vendor neutral IRTs at sub-milli-Sievert radiation dose to the standard of care CT. We found that regardless of the IRTs and multi-detector CT vendors, CTDIvol of 1.