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[Bittles, 2001; Woods et al., 2006; Bittles and Black, 2009; Teebi, 2010]. The proband's family is highly consanguineous: parents and grandparents are being first cousins. The inbreeding coefficient of our patient is 0.078125. This indicates that almost 8% of his genes are homozygous, or that taken at random, the boy has a 1/8 chance of being homozygous at any one of his genes. This probably explains the occurrence of multiple genetic diseases in one individual. Rural communities in certain areas in the Middle East and Asia are often tribal, tend to live in related clusters, and practice inter-marriage. This plays an important role in increasing the prevalence of recessive disorders. Developing strategies that are community and tribal friendly may have an impact on the belief and attitude of the community at large towards consanguinity [Balgir, 2008]. Efforts are currently in place to Screening Library decrease the effects of consanguinity on community health. These interventions include health education, pre-marital counseling, prenatal diagnosis, newborn screening, and recently pre-implantation genetic diagnosis. Al-Arrayed and Hafadh [1997], published an experience on premarital counseling in Bahrain where the burden of genetic blood disorders has long been recognized. Premarital Selleckchem EX-527 counseling provides an opportunity to intervene according to the identified risks. Memish and Saeedi [2011], reported on a 6-year outcome of the national premarital screening and genetic counseling program for sickle cell disease and ��-thalassemia in Saudi Arabia. Of 1,572,140 persons screened between 2004 and 2009, 70, 962 (4.5%) were positive (carriers or cases) for sickle cell disease while 29,006 (1.8%) were carriers or cases of ��-thalassemia. This program managed to increase the number of voluntary Pramipexole cancellation of marriage proposals among at-risk couples more than five folds (from 9.2% to 51.9%, P?