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This finding is confirmed in our experience in more than 600 STEMI patients undergoing PCI and prolonged bivalirudin administration up to 40 hours after PCI (unpublished data). IV.?BIVALIRUDIN IN NSTEMI SETTING Randomized trials testing the use of bivalirudin in NSTEMI setting are listed in Table 3. Table 3. Summary on trials for bivalirudin in NSTEMI setting. The Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) was a prospective, open-label trial, enrolling patients with moderate- Pramipexole or high-risk NSTE-ACS, with a prevalence of NSTEMI patients (59%)20. This study compared three different therapeutic strategies: UFH or enoxaparin plus GPI, bivalirudin plus GPI, or bivalirudin alone (with provisional use of GPI during PCI). All patients underwent coronary angiography within 72 h after randomization (median of 19.5�C19.8 h). Patients on GPI had a further randomization in a two-by-two factorial design to receive the GPI either immediately after randomization (upstream) or to defer administration in the cath-lab at PCI starting. The endpoints of composite ischemia (death, myocardial infarction, or unplanned revascularisation for ischemia), major bleeding, and net clinical outcomes (combining composite ischemia or major bleeding), were evaluated at 30-day. There were no significant differences in the rate of primary or secondary outcomes evaluated at 30 days between patients Screening Library who receiving bivalirudin plus GPI and patients treated by UFH plus GPI (composite ischemia rate: 9 vs. 8%, p= 0.16; major bleeding: find more 8 vs. 7%, p=0.32; net clinical outcomes: 15 vs. 13%, p=0.1). Rates of composite ischemia were similar in those who received bivalirudin alone and those who received UFH plus GPI (9 vs. 8%, p=0.45); however, patients who received bivalirudin showed a significantly reduction of major bleeding, compared to UFH plus GPI group (4 vs. 7%, p