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.. Serum nitrite The serum nitrite levels significantly increased in Group II when compared to normal control (Group I). The EEAV treatment (100 and 300 mg/kg, p.o.) significantly decreased the levels of serum nitrite when compared to disease control animals. Similar decrease in serum nitrite levels was also observed in gabapentin treated animals [Figure 2]. Figure 2 Effect of ethanolic extract of Aloe vera on calcium and myeloperoxidase. Units of calcium (ppm/mg); myeloperoxidase (U/g); all values are shown as mean �� standard error of the mean and n = 8; *indicates P ERK inhibitor Calcium and MPO levels in sciatic nerve homogenate: There was a significant increase in calcium and MPO levels in disease control group (II) when compared to the normal group (I). Gabapentin treated group (III) and groups treated with 100 and 300 mg/kg, p.o. of EEAV respectively showed significant decreased levels of calcium and MPO on comparison OPHN1 with control [Figure 2]. Effect of ethanolic extract of A. vera on serum in vivo anti-oxidant parameters After SCNL, on day 21 there was a significant decrease in the levels of in vivo anti-oxidants like SOD, catalase, reduced glutathione and significant increase in malondialdehyde levels in Group II on comparison with Group I supporting the role of oxidative stress in neuropathic pain. Treatment with gabapentin and EEAV (100 and 300 mg/kg, p.o.) significantly increased the levels of in vivo anti-oxidant like SOD, catalase, reduced glutathione and significantly lowered the malondialdehyde levels [Figures ?[Figures33 and ?and44]. Figure 3 Effect of ethanolic extract of Aloe vera on super oxide dismutase (SOD), catalase CCI-779 molecular weight and glutathione (GSH). Units of SOD: U/g; catalase: H2O2 consumed/min/mg of tissue; GSH: ��g of GSH/g of tissue; all values are shown as mean �� standard error ... Figure 4 Effect of ethanolic extract of Aloe vera on lipid peroxidation (LPO). Units of LPO (nmoles of malondialdehyde/mg of tissue); all values are shown as mean �� standard error of the mean and n = 8; *indicates P
