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After establishing normality of distribution, t-tests were used to test for differences in continuous lazabemide variables. All data summaries and statistical analysis were conducted using SAS 9.3. Ethical approval for the study was obtained from the University of Zambia Research Ethics Committee and the Boston University Institutional Review Board. A waiver of informed consent for patients participating in the study was granted by both ethical review boards. Additional approval for conducting the study was received from the Zambian Ministry of Health. Our study was conducted between September 2011 and December 2012. A total of 3425 patients arriving alive to the Emergency Centre with evidence of injury were enrolled in the registry. There were an additional 1307 patients brought in dead to UTH; 73 (5.6%) of these were determined to have died from trauma-related injuries and are included in our analysis, for a total of 3498 trauma patients. Fig. 1 shows the study profile of trauma registry patients. Of the 3498 trauma patients enrolled in the registry, the majority were male (71.8%); young, with a median age of 24?years; and had injury occurring either at home or on a paved road and in Lusaka District (80.1%). Overall, males had a slightly older age at presentation (median age 25?years, IQR?=?22) than females (22?years, IQR?=?25; p?DAPT solubility dmso an IQR of 1.0 ( Table 1). The majority of patients were transported to the hospital by private vehicle (51.8%) or by public transportation (37.1%). Only 5.8% arrived by emergency transportation services available in Lusaka. A large percentage of patients arrived within 6?h of injury (62.2%), although only 21.6% of patients arrived within 1?h. The overall median time from injury to arrival at hospital was three hours (IQR?=?12.2). Fig. 2 depicts the mechanisms of injury. Falls (26.3%), road traffic accidents (25.6%) and assault (20.0%) were the commonest injuries, although there was marked variation by age (Table 2). Assault was the most common mechanism of injury reported in patients aged 21�C50?years, with a larger percentage of men (22.2%) than women (16.0%, p?Veliparib purchase assault. Location of injury from assault also varied by gender, with a larger percentage of women (71.2%) than men (34.1%, p?