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The observed mean differences of the skin dose parameters based on different algorithms range from 4.2% for Dmax to 8.2% for D10cm3. These ranges are in agreement with a 5-10% difference for skin point doses at different distances from the breast center, calculated with TG-43 and Monte Carlo simulations [4]. The difference of Dmax of lung and ribs has been previously reported for TG-43- and Acuros-based calculations of interstitial Etoposide purchase implants with metal catheters [15]. Reported results seem to indicate a ~2% larger impact of metal catheters on the differences in Dmax in comparison to the present results for plastic catheters. A direct comparison of reported skin doses is unreliable, as in addition to different applicator materials also the definition of the skin structure for DVH evaluation was different in the present study. Zourari et al. reported 4% difference of Dmax for lung and rib when comparing TG-43 and a different commercially available model based dose calculation algorithm [16], which is in the range of the ~2% and ~5% differences we have observed for rib and lung for Acuros. As in the present study, they found the largest difference for the D10cm3 of the skin (6% vs. 8% in the present study). Even though the effect of using an advanced dose calculation algorithm check details as such is systematic, its impact on dose parameters is location dependent. Therefore, individual planning in principle adds to more accuracy of dose-response for retrospective analysis and prospective treatment planning. This effect could not be found in cervix cases. Effects due to rectum filling or packing causing low density HSP90 or even areas filled with air had no major impact on dosimetric parameters analyzed. However, the phantom study showed an impact of applicator material when the titanium applicator seems to have more of a shielding effect compared to the plastic. Although this effect was small (