Interesting Study Reveals The Deceiving Tactics Of Wnt Saracatinib

Many tumor cells were positive for ALDH1 and CD44 in both intestinal-type and diffuse-type GC (Fig.?1a, b, d and e). CD133 was expressed in the apical membrane of the tumor cells. CD133-positive staining was observed in intestinal-type and diffuse-type GC with partial glandular formation (Fig.?1c,f). In GC, the percentage of ALDH1- and CD44-stained tumor cells ranged from 0% to 90%, and the percentage of CD133-stained tumor cells ranged from 0% to 40% (Table?1). More than half C59 wnt supplier of ALDH1- and CD44-positive cases contained over 50% positive cancer cells. CD44 expression was detected in whole tumor lesions. Most CD133-positive cases included less than 20% positive cancer cells. For each CSC marker, immunostaining was considered positive when at least 10% of tumor cells were stained, on the basis of previous reports.25�C27 selleck kinase inhibitor The relationship of CSC marker staining to clinicopathologic characteristics was investigated (Table?1). ALDH1-positive GC cases showed more advanced T stage (P= 0.02, ��2 test), TNM stage (P= 0.01, ��2 test), and tended to be intestinal histology (P ALOX15 positive cases and 52% negative cases. CD44-positive patients had significantly lower survival probability than CD44-negative patients (P