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Simultaneous administration of these two drugs might have interfered with the metabolism of oxcarbazepine thereby increased its serum concentration to a higher level that produced such toxicity. Replacing oxcarbazepine with levetiracetam abolished such interaction and the rash subsided. The dechallenge test was positive but rechallenge was not done. According to Naranjo��s scale [4] it appears to have a probable causal relation with a score of 5 and WHO-UMC [5] causality assessment also shows a probable/likely cause of it. On the other hand according to modified ��Hartwig and Siegel �C 1992 ADR Severity Assessment Scale�� [6] it was calculated as a ��moderate Cilengitide level 3�� type of ADR. There are many reports of dose dependent cutaneous toxicity of carbamazepine but there are scanty such reports of drug interactions leading to oxcarbazepine induced cutaneous adverse reaction as possibly happened in this case. Two studies done earlier documented cutaneous toxicity with oxcarbazepine depicted in the [Table/Fig-1]. One of this study documented no significant association between HLA-B*1502 and OXC-MPE [2]. [Table/Fig-1]: Literature reporting oxcarbazepine induced maculopapular rash Conclusion Oxcarbazepine may interact with INH when administered simultaneously leading to such cutaneous ADR. It is probably better to avoid the co-administration of such drugs and opt for alternative anticonvulsant AMD3100 order treatment option keeping unchanging the treatment antitubercular drug regimen as far as practicable. Exercising caution is essential to avoid this preventable problem. Notes Financial or Other Competing Interests None.A 22-year-old male student came to the surgery department of a tertiary care hospital in South, Tamil Nadu (India) with complaint of recurrent multiple subcutaneous swellings, presenting as tumour www.selleckchem.com/products/ci994-tacedinaline.html like nodules, biggest over the anterior abdominal wall measuring 12 cm in diameter [Table/Fig-1,?,2].2]. The nodules were big, disfiguring and some of them showed ulceration. Clinically the patient was symptom free. Blood investigations done showed no signs of immune suppression. Internal organs were free of any lesion in CT. He had past history of surgery for nasal mass seven years back. He developed all these masses since 10 y. He also developed mental depression due to disfiguring masses and had been on antidepressant therapy for the same. The biggest mass in the anterior abdominal wall was surgically excised. [Table/Fig-1]: Multiple disfiguring tumour like nodules over the body [Table/Fig-2]: Multiple disfiguring tumour like nodules over face Gross examination of the excised mass from abdomen wall [Table/Fig-3] showed a nodular, firm, solid, whitish mass measuring 12 x 12 x 6 cm just below the skin.