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Eighty-nine percent of those surveyed had some knowledge of herpes labialis; 92% were able to refer to at least one symptom of herpes labialis, 91% were able to identify correctly his infection from pictures, and 45% had experienced personally at least one episode of herpes labialis infection. The majority of the individuals suffering from herpes labialis self-medicated using a topical therapy. Women were found to AG-014699 research buy be affected more commonly by herpes labialis than men [OR 1.42 (1.18�C1.70)], and women were also more likely to recognize the disease [OR 1.65 (1.30�C2.08)] and to seek medical advice for the condition [OR 1.38 (1.12�C1.70)]. In conclusion, herpes labialis is a common and well-known condition, and it is often self-diagnosed correctly, as the prodromal phase and the use of self-medication are very common. J. Med. Virol. 84:132�C137, 2011. ? 2011 Wiley Periodicals, Inc. ""Persistent infection by high-risk human papillomavirus LDK378 cost is a necessary cause for cervical cancer. DNA-based human papillomavirus (HPV) assays show high sensitivity but poor specificity in detecting high-grade cervical lesions. Assays detecting mRNA of the oncoproteins E6 and E7 show higher specificity but lack either detection of all high-risk genotypes or the ability to specify the detected genotypes. The aim of this study was to evaluate the clinical performance of the NucliSENS EasyQ HPV assay in comparison with the Hybrid Capture 2 test (HC2) and the CLART Human Papillomavirus 2 assay (CLART), using a clinical cut-off of cervical intraepithelial neoplasia grade 2 or worse. In the 554 studied women, the lowest HPV positivity rate was detected for NucliSENS EasyQ HPV assay (55.1%), while HC2 and CLART showed similar results (HC2: 77.4%; CLART: 78.0%). In comparison with the other tests, the NucliSENS EasyQ HPV assay showed a lower clinical sensitivity (79.3% vs. 96.4% for HC2 and 95.9% for CLART) but a higher clinical specificity (72.6% vs. 42.8% for HC2 and 42.5% for CLART). Detection of E6/E7 mRNA transcripts may provide a higher specificity for cervical intraepithelial neoplasia grade 2 lesions or worse, since the oncogenic potential of HPV infection depends on the over-expression Quetiapine of these two oncoproteins. J. Med. Virol. 85:1235�C1241, 2013. ? 2013 Wiley Periodicals, Inc. ""BK virus (BKV) and JC virus (JCV) are human polyomaviruses that cause asymptomatic latent infections. Under immunosuppression, BKV-associated nephropathy has been documented in Kuwait and elsewhere. Even though different BKV and JCV genotypes with distinct geographical distribution have been described, the genotype of polyomavirus detected in Kuwait is still unknown. The aim of this study was to determine the genotypes of BKV and JCV detected in renal transplant recipients.
