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While the average stature women (1 and 2) are the same height (1.62?m) with the same lean mass (48?kg), woman 1 has a normal percentage body fat (25%) while that of woman 2 is considered unhealthy (40%). BMI of woman 1 is in the ��normal�� category (24.2?kg/m2), while that of woman 2 is correctly categorized as ��obese�� (30.3?kg/m2). The short stature skeletal dysplasia women (3 and 4) have the same percent body fat as the average stature women, 25% and 40%, respectively. Although women 3 and 4 weigh less than the average stature women, they are also considerably shorter (1.16?m). Hence, the BMI of woman 3 is 29.3?kg/m2, 5 units higher than her average stature counterpart with comparable percent body fat (25%). Similarly, woman 4 has a BMI of 36.6?kg/m2, >6 units greater than woman 2 with the same percent body fat (40%). The BMI is certain to be associated Ceftiofur with body fat in people with skeletal Ceritinib mw dysplasias, and obesity is a concern in those with skeletal dysplasias as in the general population��perhaps even more so, given that there is a smaller body frame on which to accumulate excess weight. But more information is needed to properly interpret calculated BMI values in skeletal dysplasias, or to determine whether other measures, such as skinfolds, body circumferences, or more direct measures of body composition, are more relevant. Moreover, the link between the degree of body fatness and morbidity and mortality has been entirely unstudied in this population. Without such an evidence base, average stature BMI recommendations must not be applied to short stature individuals as an indicator of fatness, disease, or mortality risk. Studies to address these issues are underway. We would like to acknowledge the Medical Advisory Board of the Little People of America for fruitful discussion about this topic as we prepared this manuscript. ""Previous studies have shown that over 40% of babies Caspase inhibitor clinical trial with Down syndrome have a major cardiac anomaly and are more likely to have other major congenital anomalies. Since 2000, many countries in Europe have introduced national antenatal screening programs for Down syndrome. This study aimed to determine if the introduction of these screening programs and the subsequent termination of prenatally detected pregnancies were associated with any decline in the prevalence of additional anomalies in babies born with Down syndrome. The study sample consisted of 7,044 live births and fetal deaths with Down syndrome registered in 28 European population-based congenital anomaly registries covering seven million births during 2000�C2010. Overall, 43.6% (95% CI: 42.4�C44.7%) of births with Down syndrome had a cardiac anomaly and 15.0% (14.2�C15.8%) had a non-cardiac anomaly. Female babies with Down syndrome were significantly more likely to have a cardiac anomaly compared to male babies (47.6% compared with 40.4%, P?
