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Lungs of 3-week-old wild-type Balb/c mice were exposed by pharyngeal aspiration nine times over 3?weeks to DEP Ozanimod ic50 at 1.2 or 6.0?mg/kg body weight, house dust mite (HDM) at 0.8, 1.2 or 6.0?mg/kg of DEP in combination with HDM, or the same volume (50?��L) of 0.9% sterile saline. In young mice, exposure to 1.2?mg/kg of DEP caused no detectable lung inflammation, but 6.0?mg/kg of DEP induced neutrophilic influx. Compared to HDM or DEP alone, mice exposed to either dose of DEP together with HDM demonstrated increased allergen-specific IgE, lung inflammation, airway hyperreactivity, goblet cell metaplasia, Th2/Th17 cytokines, dendritic cells, activated T cells, effector T cells, and IL-17pos and IL-13pos/IL-17Apos T effector cells. In young mice, co-exposure to DEP and HDM together exacerbated allergic sensitization and induced key characteristics of more severe asthma, including IL-17A, IL-17pos and IL-13pos/IL-17Apos T effector cells. While exposure to 1.2?mg/kg DEP alone caused no detectable changes, it did exacerbate allergic sensitization and asthma characteristics to a similar degree as a five-fold higher dose of DEP. This study demonstrates that exposure to DEP, even at a dose that alone causes no inflammation, exacerbates allergic asthma in young animals and suggests the importance of preventive measures to reduce the exposure of children to traffic related air pollution. ""Liu T-H, Lin Y-R, Yang K-C, Tsai Y-G, Fu Y-C, Wu T-K, Wu H-P. Significant factors EGFR inhibitor associated with severity and outcome of an initial ATP12A episode of acute urticaria in children. Pediatr Allergy Immunol 2010: 21: 1043�C1051. ? 2010 John Wiley & Sons A/S The aim of this study was to determine the predictive factors of severity and duration of an initial episode of acute urticaria in children. This was a retrospective study of 1120 children of