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Materials and Methods Patients diagnosed with gastric cancer and click here eligible for curative resection (R0) at either Peking University People's Hospital, China or Seoul St. Mary's Hospital, Korea between 1998 and 2009 were included in this study. We analyzed patient demographics, tumor factors, surgical factors, and survival. Patients who underwent R0 resection but who had no other history of cancer were included. Patients were excluded if they underwent neoadjuvant chemotherapy, wedge resection, or endoscopic mucosal resection. tumor-node-metastasis (TNM) classification was based on the 7th edition of the American Joint Committee on Cancer staging system. D1 or D1+ lymphadenectomy was performed for early gastric cancer. D2 or D2+ (D2+14v, or +12p, or +8p, or +16a) lymphadenectomy was performed for advanced cancer. The criteria for follow-up and recurrence were similar for both Korean and Chinese patients. Neratinib research buy Follow-up evaluation was repeated every 3 months for 2 years, every 6 months from the third to fifth post-operative year, and every year thereafter. The follow-up rates were 92.5% and 94.8% for Chinese patients and Korean patients, respectively. 1. Statistical analysis The Statistical Package for the Social Sciences (SPSS) version 17.0 (SPSS Inc., Chicago, IL, USA) was used. The chi-square test was employed to assess differences in the categorical clinicopathological variables. The independent t-test was used to evaluate differences in continuous variables. Overall survival (OS) was calculated Quinapyramine from the time of surgery to the last follow-up or date of death. For patients who experienced recurrence, progression-free survival (PFS) was calculated as the time from surgery to the time of first recurrence; for those with no recurrence, PFS was defined as the time from surgery to the last follow-up or death. Univariate survival analysis of OS and PFS was estimated using the Kaplan-Meier method. The Cox proportional hazards model was used for multivariate analysis. Variables in the model included patient group, gender, age, body mass index (BMI), family history of cancer, operation type, digestive tract reconstruction methods, lymphadenectomy type, tumor location, tumor size, tumor differentiation, TNM stage, adjuvant chemotherapy, and number of harvested lymph nodes. P-values