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05), suggesting that low-dose tibolone may slow down uterine atrophy, which is not consistent with previous reports[4,16]. The reason for the difference may be related to the study population. Females who went into early menopause were the subjects of our study and their average menopause time was 3.04��0.89 years, which is the critical period of uterine volume contraction[18], and hormone therapy largely affected the volume of the uterus. Some studies have shown that short-term tibolone therapy resulted in mild proliferation of the endometrium, which was more remarkable than estrogen-progesterone treatment, while long-term treatment with tibolone led to an atrophic endometrium[9-11]. Another study revealed that postmenopausal women given a low-dose of tibolone for Cytoskeletal Signaling inhibitor 12 to 24 months were Fleroxacin found to have a larger endometrial thickness than those without therapy[4]. Our findings showed that endometrial thickness in patients treated with tibolone at a daily dose of 1.25 mg was similar to that in patients before therapy in the both the treatment and control group (P>0.05). Our results are not entirely consistent with the previous research and this may be associated with different study durations. A 15% incidence of endometrial polyps was reported within 2 years of tibolone therapy[24]. Histological detection of endometrial specimens collected from women undergoing tibolone treatment revealed that the proportion of changes of proliferative phase endometrium increased and the proportion of atrophic endometrium declined[25]. Another study showed a low prevalence of endometrial hyperplasia[26]. In the present study, we found that there was no significant difference in the proportion of pathologic alteration of the RO4929097 concentration endometrium at abnormal uterine bleeding between the treatment and control group (P>0.05). Meta-analyses recommend 3-5 mm as the cut-off value of endometrial thickness during post-menopausal uterine bleeding[27], while the guidelines of the American College of Obstetricians and Gynecologists defines 5 mm as the cut-off value for endometrial curettage, with a sensitivity of 90% and negative predictive value of 99%[28], which has been widely employed in China. Hanegem and colleagues[29] reported a sensitivity of 95% and a specificity of 47% when using the 4 mm cut-off value of endometrial thickness, and a sensitivity of 88.6% and a specificity of 90.6% when using 6 mm as the cutoff. It was considered that endometrial curettage was not needed in women who received MHT and had an endometrial thickness of
