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1% (609/2021) in 2012, P this website in 2012 (NS). It can be assumed that this factor hardly contributes to the observed change in diabetes prevalence in Bulgaria. Arterial hypertension changed nonsignificantly among the diabetic subjects from 80.5% in 2006 to 84.5% in 2012, a relative increase by 4.96% (Table 2). The prevalence of arterial hypertension in the general population AZD9291 for the same period did not change significantly either: from 43.9% (1053/2396) in 2006 to 41.3% (839/2020) in 2012, P = NS. Other factors that might contribute to the observed diabetes development in our population include the male gender and the age. An increase in diabetes prevalence was found in both genders, but more markedly in the males, in whom it was marginally significant (by 2.3% or a relative increase of 25%: 9.2% in 2006 vs. 11.5% in 2012, P = 0.06). In the females, the increase was minimal, from 6.9% in 2006 to 7.8% in 2012, a relative increase of 13% (P = NS). Age is a well-known risk factor for diabetes mellitus. The Canadian Health Agency reported in 2011 a diabetes prevalence in the country in 2008/2009 of 8.7% (95% CI: 8.72�C8.74) among the adult population over 20 years of age. That is, 1 in every 11 Canadian citizens was a diabetic, which is similar to our results. The authors observed an increase in the prevalence of the disorder with age, most markedly after the age of 40. This observation might be explained by the decline in insulin production and tissue utilization. Therefore unsurprisingly, the elderly have an increased probability of developing type 2 diabetes. The Canadian researchers reported the highest prevalence in the age group 75�C79. Nevertheless, half of the diabetic subjects YES1 were in active age (25�C64 years). The Canadian Health Agency reported an increase of diabetes prevalence to 9.2% in 2011 [Unpublished analysis using 2008/2009 data from the Canadian Chronic Disease Surveillance System, Public Health Agency of Canada; 2011]. In our study, we found that age was linked strongly with the increase in diabetes prevalence between 2006 and 2012. Moreover, the age group 50�C59 seems critical with an increase in the disease prevalence from 9.4% (49/523) in 2006 to 15.7% (53/338) in 2012, P