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For standing and walking, ACL force increased as tibial slope was increased; for squatting, PCL force decreased as tibial slope was increased. The effect of changing PTS on ACL force was greatest for walking. The true effect of changing tibial slope on knee-joint biomechanics may only be evident under physiologic loading conditions which include muscle forces. ? 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:223�C231, 2011 ""Anterior cruciate ligament (ACL) injury continues to be at the forefront of sports injury concerns because of its impact on quality of life and joint health prognosis. One strategy is to reduce the occurrence of this injury by identifying at-risk subjects based on key putative risk factors. The purpose of our study was to develop models that predict the structural properties of a subject's ACL based on the combination of known risk factors. 740 Y-P in vitro We hypothesized ALG1 that the structural properties of the ACL can be predicted using a multi-linear regression model based on significant covariates that are associated with increased risk of injury, including age, sex, body size, and ACL size. We also hypothesized that ACL size is a significant contributor to the model. The developed models had predictive capabilities for the structural properties of the ACL: load at failure (R2?=?0.914), elongation at failure (R2?=?0.872), energy at failure (R2?=?0.913), and linear stiffness (R2?=?0.756). Furthermore, sex, age, body mass, BMI, and height were contributors (p?GABA cancer contributor to any structural property. The clinical significance of this research is its potential, after continued development and refinement of the model, for application to prognostic studies that are designed to identify individuals at increased risk for injury to the ligament. ? 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 993�C1001, 2011 ""Methotrexate (MTX) chemotherapy is known to cause bone loss which lacks specific preventative treatments, although clinically folinic acid is often used to reduce MTX toxicity in soft tissues. This study investigated damaging effects of MTX injections (0.75?mg/kg/day for 5 days) in rats and potential protective benefits of fish oil (0.25, 0.5, or 0.75?ml/100?g/day) in comparison to folinic acid (0.75?mg/kg) in the tibial metaphysis. MTX treatment significantly reduced height of primary spongiosa and volume of trabecular bone while reducing density of osteoblasts.