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Table 2 Serum levels of angiogenic proteins in JIA in comparison to healthy children. In JIA children serum VEGF levels correlated significantly with CRP and ESR (R = 0.39 and R = 0.41, resp.; p Lapatinib nmr of angiogenic proteins in serum and synovial fluid showed significantly Liothyronine Sodium higher levels of VEGF and sVEGF-R1 in synovial fluid (p = 0.004 and p Crenolanib mw process and is controlled by a variety of stimulators and inhibitors [19]. It is crucial to chronic inflammation and implies being essential pathogenetic mechanism in both the establishment and persistence of RA and, probably, JIA [20]. In this study we assessed five angiogenesis markers in patients with JIA. Among them were ANG-1 and ANG-2, to the best of our knowledge for the first time evaluated in JIA. Levels of these markers were correlated with signs of synovial inflammation measured using PDUS imaging. Elevated serum levels of VEGF and its receptors have been previously shown in adult patients with RA [21, 22].