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Finally, the care program has the potential to maximize the beneficial effects of other recovery enhancing strategies, such as the use of minimally invasive surgery. Acknowledgments This study was funded by ZonMw, an organization for health research and development in the Netherlands (project numbers 150020037, 171102015, and 92003590). Abbreviations CONSORT CONsolidated Standards Of Reporting Trials DMQ Dutch Musculoskeletal Questionnaire EQ-5D EuroQol-5D GP general physician GSES General Self-Efficacy Scale ICER incremental cost effectiveness ratio IQR interquartile range Ponatinib in vitro JCQ Job Content Questionnaire LAS laparoscopic adnexal surgery OP occupational physician OT occupational therapist PMS Pearlin Mastery Scale RI-10 Recovery Index-10 RTW return to work SF-36 Short-Form Health Survey TAH total abdominal hysterectomy TLH total laparoscopic hysterectomy TP time period VAS Visual Analogue Scale VH vaginal hysterectomy Multimedia Appendix 1 Screenshots of ikherstel. Click here to view.(1.5M, ppt) Multimedia Appendix 2 CONSORT-EHEALTH checklist V1.6.2 [34]. Click here to view.(984K, pdf) Multimedia Appendix 3 Grant Proposal. Click here to view.(150K, pdf) Multimedia Appendix 4 Letter of Grant Approval. Click here to view.(41K, pdf) Footnotes Conflicts of Interest: EVB, AVN, HAB, JRA, and JAH are the developers of the care program under study.Among the 100 HIV-1 infected study participants, Imatinib manufacturer 74 were males and 26 females. Quinapyramine The age range was 21 to 70 years and heterosexual promiscuity was the most common mode of transmission (55%). The various first line ART combinations received by the study participants were (a) 3TC + AZT + NVP (n = 53), (b) 3TC + AZT + EFZ (n = 14), (c) D4T + 3TC + NVP (n = 13), (d) D4T + 3TC + EFZ (n = 8), (e) 3TC/D4T + AZT + NVP (n = 6), (f) 3TC + AZT + NVP/EFZ (n = 4), (g) 3TC/D4T + AZT + NVP/EFZ (n = 2). 3.1. HIV-1 RNA Levels and CD4+ T-Cell Counts Out of the 100 HIV-1 infected study participants, 81 showed HIVDR prevention (HIV-1 RNA level 1000/mL (range: 1,026�C963,000) (median: 7,421). CD4+ T-cell count in 10 study participants was >500cells/?L, 200�C499cells/?L in 64, and 26 had 1000/mL are shown in Table 1. Based on the recommendations by WHO to monitor HIVDR prevention and associated factors in sentinel ART sites, individuals showing HIV RNA level (