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60, 0.63 and 0.69 respectively when RF and eNO were considered alone and combined. Conclusion:?eNO was a fair predictor of PRAE when RF were present. RF and eNO together only slightly improved the prediction capacity. For routine clinical practice the presence of RF can therefore be considered as a clinically more adequate predictor for PRAE. VANDELEUR M1,2,4, NIXON G1,2, ARMSTRONG D3, ROBINSON P4, HORNE R1 1The Ritchie Centre, Monash Institute of Medical Research, Monash University, 2Melbourne Children's Sleep Centre, Monash Children's Hospital, Clayton, 3Department of Paediatrics, Monash University, 4Department of Respiratory Medicine, Royal Children's Hospital, Melbourne Introduction:?In adults with cystic fibrosis (CF) sleep disturbance is common and associated with depressed mood however there is a paucity of international data regarding children. Aim:?To determine sleep Duvelisib concentration patterns and quality in children with clinically stable CF and healthy controls and to examine the relationship to mood. Methods:?Children with CF, free flupentixol from pulmonary exacerbation and age matched healthy control children (age range 7�C18?y) were recruited. Each completed 2 weeks of sleep diary together with sleep questionnaires (OSA-18, Paediatric Daytime Sleepiness Scale (PDSS), Sleep Disturbance Scale for Children (SDSC)). Overnight SpO2 was measured using pulse oximetry. Questionnaires were used to assess mood (Children's Depression Inventory (CDI), Beck Depression Inventory-Youth (BDI-Y)). Data were compared between groups with one way ANOVA with Student Newman Keuls posthoc analysis if normally distributed or Kruskal-Wallis one way ANOVA on Ranks with Dunns posthoc analysis if not. Results:?46 CF (24?M/22?F) and 39 control (19?M/20?F) children well-matched for age completed the study. Mean (��?SD) FEV1 in the CF group; 80?��?19% predicted. CF and control subjects reported no significant see more differences in sleep duration or frequency of night waking. Children with CF had significantly lower mean SpO2 than controls (96.9?��?1.7% vs. 98.4?��?0.8%, p?