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Men were affected more frequently than women, with a male/female ratio of 1.6:1. In two cases, information on clinical presentation was not available. Of the remaining 13 cases, 4 (30%) Quinapyramine presented with gastrointestinal bleeding and 5 (38.5%) with a mass lesion or vague abdominal discomfort. In three patients, GIST was an incidental gastroscopic finding after evaluation for iron-deficiency anemia, and in one patient it was identified during a screening colonoscopy. The primary sites of involvement are described in Table 1 and included most commonly the stomach. At diagnosis, metastasis to the liver were demonstrated by imaging in 3/15 (20%) of patients. Pathologic features and molecular analysis GIST ranged in size from 0.4 to 22 cm. The largest tumor was seen in the retroperitoneum. In one patient, the tumor was MS-275 manufacturer although it is not entirely specific.21 Thirteen patients (86.8%) were found to be CD117 positive, while the remaining two were negative. Furthermore, all 15 examined specimens exhibited CD34 positivity. Pathologic features were assessed in order to assign tumors into risk groups (Table 1). According to the Miettinen classification,8 which takes into consideration the primary site, size, and mitotic count, 80% of our patients�� tumors were classified as probably malignant, whereas according to Fletcher classification,7 GDC-0449 molecular weight which takes into account the size and mitotic activity, 53% were classified as high risk. Mutational analysis was available in nine patients. Eight patients harbored the exon 11 cKIT mutation and one the exon 9 cKIT mutation. Treatment and toxicity Fourteen patients received upfront surgery with curative intent. One patient with advanced gastric GIST and hepatic metastases did not undergo surgery. A surgical procedure, which included extensive resection of primary site with liver metastases, was carried out in two patients. Totally, 12 patients received imatinib therapy: 8 in the adjuvant and 4 in the advanced stage. The majority of these patients tolerated imatinib treatment well with mild toxicity, as previously reported22,23 (Table 1).