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A convenience sample of 16 patients (10�C23 years) that have consulted with established diagnosis of PBO in Ibrutinib solubility dmso a tertiary care clinic were studied. Fourteen healthy matched subjects were selected from the community to serve as controls. They performed resting lung function tests and cycle incremental cardiopulmonary exercise tests. Peak aerobic capacity (peak ) was significantly lower in patients compared to controls (84?��?15 vs. 101?��?17% pred; P?TRIB1 Pulmonol. 2014; 49:911�C918. ? 2013 Wiley Periodicals, Inc. ""Advanced training in interventional pulmonology (IP) includes a multidisciplinary approach to a wide variety of pathologic conditions affecting different age groups. The role of the interventional pulmonologist in the pediatric patient population has not been described. We report our experience of the care of pediatric patients by IP at an academic institution. A retrospective review of inpatient and outpatient IP procedures from 2008 to 2011 was performed. All patients' less than 21 years of age at the time of their procedure were identified. Data regarding age, procedure performed, pre-operative diagnosis, results, and complications were collected. Thirty-five patients younger than the age of 21, with 14 of these patients being under the age of 18, were identified. Fifty-six procedures were performed on the entire cohort, MK-2206 manufacturer 30 as inpatient procedures and 26 as outpatient procedures. There were no deaths or major complications related to any procedure. We identified a cohort of pediatric patients that were able to successfully undergo diagnostic and therapeutic procedures under the direction of an experienced IP team. Cases included the evaluation and management of both malignant and benign complex airway and pleural diseases. There was no major morbidity or mortality related to our procedures, demonstrating an ability to safely evaluate and manage complex airway and pleural disease in the pediatric population. Pediatr Pulmonol. 2014; 49:597�C604. ? 2013 Wiley Periodicals, Inc. ""Respiratory syncytial virus (RSV) is one of the leading causes of acute lower respiratory infection (ALRI) in infants and young children.