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6 mmol/L) during the oral glucose tolerance test (OGTT) is a strong predictor of future diabetes risk. Objective: We tested the hypothesis that a 1-h glucose concentration ��155 mg/dL is associated with lower ��-cell function in overweight/obese youth. Research design and methods: One hundred and thirteen diabetes free overweight/obese youth aged 10�C20 yr, underwent evaluation of ��-cell function during a 2 h hyperglycemic clamp ?225 mg/dL (12.5 mmol/L), and insulin sensitivity during a 3 h hyperinsulinemic�Ceuglycemic clamp, and a standard 2 h OGTT. Body composition Alectinib manufacturer and abdominal adiposity were determined by DEXA and CT scan. The disposition index (DI) was calculated as the product of first-phase insulin secretion and insulin sensitivity. Subjects were divided into two categories of 1-h plasma glucose concentration: Sitaxentan 1-h glucose buy Anticancer Compound Library and in 6-yr prospective. Subjects: Danish 8- to 10-yr-olds and 14- to 16-yr-olds from the European Youth Heart Studies I and II. Methods: Cross-sectional (n = 386) and prospective (n = 246) linear regressions of baseline concentrations of plasma biomarkers and insulin insensitivity at baseline and 6 yr later. Adjustments were made at four progressive steps for sex, sexual maturity, body mass index (BMI), other biomarkers, physical activity, and school location as well as baseline insulin insensitivity in prospective analyses. Insulin insensitivity was measured using homeostasis model assessment standardized to the sample mean [homoestasis model assessment (HOMA) Z-scores]. Plasma biomarkers were quantified using solid-phase protein immunoassays. Overweight was defined as the highest BMI tertile.