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05% tretinoin (Locacid, Pierre-Fabre) was used in 74 subjects. Patients used the topical specimen on the affected GSK2656157 order area twice a day. They prolonged its contact with the mucous membranes with occlusive swabs or spatulas. In case of irritation, smearing with 5% Solcoseryl paste (ICN Polfa Rzeszow) or stopping application for 24�C48 h was recommended. Topical treatment was used for at least 8 weeks. Cryosurgery was performed in 63 patients. All procedures were performed under local anesthetic of 2% lignocaine using Cryo-S engine with nitrous oxide as a cooling medium. All procedures were performed by the spraying method, using two cycles of freezing, each 40 s in length, with an interval of 2�C3 min between them. In the case of multifocal changes, a multi-step approach with 2�C3-week intervals between follow-up visits was taken. In case of pain, over the counter non-steroidal anti-inflammatory drugs and 5% Solcoseryl paste (ICN Polfa Rzeszow) were recommended after the surgery. Forty-one patients underwent surgical treatment. The surgeries were performed under local anesthetic of 2% lignocaine. Excisions were performed within I-BET151 solubility dmso borders of clinically visible changes. Depending on the location and size of the lesions, cavities were closed in a linear way, covered with a graft or allowed to cover with granulation tissue. Patients were monitored 2, 4, 6 and 8 weeks and then every 6 months. No significant side effects or complications during the treatment which could interrupt the therapy were observed. Regression was assumed when the changes clinically subsided. Partial regression was assumed when at least 50% of the changes subsided. Other changes were classified as no improvement/relapse. The appearance of new lesions in an adjacent area was regarded as a relapse. Statistical analysis All calculations were performed using the statistical package Statistica 8.0 (StatSoft, Inc. in 2008) and Microsoft Excel 2003. To assess the statistical significance of differences in the results of tests, ��2 was employed (depending on the number of samples and on the expected sample size, an original method of Person, test with Yates�� correction or Fisher's exact test were used). In all statistical tests the level of statistical significance was p Oxygenase of 178 patients with OL are presented in Table 1. Statistically, improvement was higher after cryosurgical treatment (77.78% vs. 54.05%, p = 0.01) and surgical treatment (75.61% vs. 54.05%, p = 0.04) in comparison to tretinoin treatment. However, there were no statistic differences noticed between surgical and cryosurgical treatment effectiveness. Table 1 Comparison of OL treatment results of 178 patients with OL There were statistically crucial differences (p = 0.002) while comparing the effectiveness of treatment (recovery vs.