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47, p Forskolin datasheet 11 covariates, we found that the BAI scores had a significant effect on the QOL of patients with PD (B = 0.70, p = 0.001, and 95% CI = 0.29�C1.10); that is, the higher the level of anxiety reported, the poorer the QOL reported. In summary, the MMSE, UPDRS part II (the level of dependency of ADL), depression, and anxiety scores were significant predictors of QOL in patients with PD. The proportion of variance (R2) explained by the regression model amounted to 70.00% (adjusted 66.20%). Table 5 shows the predictors of the PDQ-39. Table 5 Predictors of PDQ-39 in the forward multiple regression analysis (N = 134). 4. Discussion Our study demonstrated that PD patients who reported poorer QOL also had longer disease DNA Synthesis inhibitor durations, more severe PD symptoms, higher Hoehn and Yahr stages, and higher levodopa dosages, as well as higher levels of anxiety and depression, more sleep disturbances, and poorer overall cognitive statuses. The results also showed that the disease duration, severity of symptoms, and medication usage greatly influenced the QOL in patients with PD, which has been reported previously in the literature [24, 25]. Here, we found that women with PD were more likely to develop depression and anxiety and have Dipivefrine higher BDI (22, 55.10%) and BAI (38, 77.55%) scores, respectively, compared to men (22, 25.88%, and 54, 63.53%, resp.). These results were consistent with the prevalence of these disorders in the general population, where women have a twofold chance of developing depressive and anxiety disorders compared to men [25, 26]; however, our findings were different from those of several other studies that reported no sex differences in the development of depression and anxiety in the PD population [27�C29]. Regarding the presence of anxiety and depression, analysis showed that about one-third of the participants had neither depression nor anxiety. Depression alone was only noted in 2.2% of patients. Anxiety coexisted with depression in about 34.33% of patients, which is lower than the results reported by Pontone et al. [30] (55%) and Yamanishi et al. [10] (41%). Anxiety in the absence of depression was evident in about 30% of the patients in the present study, and similar findings were reported by Richard [31] and Yamanishi et al. [10]. In our study, more participants had anxiety compared to depression.