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The localization of tumors in the spinal canal was as follows: 1 thoracic (T), 2 thoraco-lumbar (T-L), and 5 lumbar (L), with cauda equina tumors being the most frequent. MRI showed low-signal intensity on T1-weighted images and high-signal intensity on T2-weighted images, both with gadolinium enhancement. Such imaging findings are typical of neurinomas [13]. All cases were diagnosed as intradural extramedullary tumors on MRI, myelography, or CTM before surgery, and confirmed during surgery. Table 2 Summary of each tumoral lesion group Six of 17 cases (35.3%) were histopathologically diagnosed as amyloidomas; they were stained with Congo Red and were Kinase Inhibitor Library positive for ��2M immunostaining (Figs. 1, ?,2).2). The mean age of this group was 56.7 years (range, 53-60 years). It is interesting that the mean duration of HD was relatively long in this group at 24.3 years (range, 20-27 years). The locations of these tumoral lesions were: 3 cervical (C), 1 T, 1 T-L, and 1 L (Table 2). In three cases, MRI showed low-signal intensity on both T1- and Isotretinoin T2-weighted images and three showed low-signal intensity on T1-weighted images, high-signal intensity on T2-weighted images, and gadolinium enhancement (Figs. 3, ?,4).4). Diagnostic images showed that these lesions were all extradural tumors. The localization was confirmed during surgery. Fig. 1 Congo Red staining of case 13. Amyloid fibrils are densely stained with Congo Red (��100). Fig. 2 Amyloid deposits are immunoreactive to anti-��2M antibody (��100). Fig. 3 Magnetic resonance imaging of T1-weighted image of a patient with amyloidoma (case 13). Fig. 4 Magnetic resonance imaging of gadolinium-enhanced T1-weighted image of a patient with amyloidoma (case 13). The other group comprised of three cases (17.6%). The mean age of this group was 55.3 years (range, 52-60 years). One patient was treated with CAPD. The mean duration selleck screening library of HD and CAPD was 8.7 years (range, 4-12 years). Two of these tumoral lesions occurred in the cervicothoracic (C-T) region and 1 in the L region (Table 2). Histopathologically, the patient treated with CAPD had tumoral calcinosis, and the other 2 had fibrous tissue with no evidence of ��2M amyloid deposition by Congo Red and ��2M immunostaining. MRI showed T1- and T2-weighted hypointense images in the case with tumoral calcinosis and T1-weighted hypointense and T2-weighted hyperintense images in the 2 cases with fibrous tissue. The tumoral calcinosis case was localized in C-T region, and the fibrous tissue cases in C-T and L regions (1 in each). These tumoral lesions were all determined to be extradural on diagnostic imaging and confirmed during surgery. There was no significant difference in age at surgery among each group. However, the difference in HD duration among each group was statistically significant (p
