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NT-proBNP was analyzed using the Roche Elecsys? 1010 bench-top analyzer for heterogeneous immunoassay (Roche Diagnostics Inc., Germany). The system involves Doxorubicin molecular weight an ElectroChemiLuminescence (ECL) machine that uses 2 polyclonal antibodies for detecting NT-proBNP. The between-run coefficient of variation for this assay platform ranges from 4.4 to 5.3% [7]. The Roche NT-proBNP assay has previously been validated for precision, specificity, stability, and utility [8]. The subjects were divided into tertiles based on plasma concentrations of NT-proBNP. Individuals in the upper tertile of NT-proBNP concentrations were classified as patients with high NT-proBNP level, and individuals in the lower and middle tertile were classified as patients with low NT-proBNP level. Normally distributed continuous variables were presented as means �� SD, whereas variables with a highly skewed distribution were presented as medians with corresponding range. Categorical variables were FARP1 presented as frequencies (percentages). Normality of distribution was assessed using histograms and quartile plots. Differences between groups with high and low NT-proBNP concentrations were analyzed using Student's t-test, the Mann-Whitney U-test, ��2 test or Fisher's exact test, as appropriate. All statistical tests were performed at significance level ��=0.05 (two-sided). The analysis is exploratory and therefore no formal a priori power analysis was performed. Associations of selected variables with high NT-proBNP level were analyzed using logistic regression models. Univariate analysis was used to determine the odds ratios (OR), their 95% confidence intervals (CI) adjusted for age and gender and p-values. Multivariate analysis was performed with adjustment for age, gender, CAD status, insulin treatment and variables selected using a stepwise procedure. Mean �� SD demographic data, concurrent medications and biochemical and hematological parameters for the study population are presented in Table 1, Table 2?and?Table 3 The subjects were divided into buy Obeticholic Acid tertiles based on plasma concentrations of NT-proBNP. Concentrations of NT-proBNP in patients of the lower, middle and upper tertile were 200 pg/mL, respectively. Patients of the lower and middle tertile were defined as having low concentration of NTproBNP, and patients of the higher tertile as having high concentration of NTproBNP. Patients with high NT-proBNP concentrations were older (p