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""Cite this as: P. Maestrelli, Clinical & Experimental Allergy, 2011 (41) 454�C456. ""The prevalence of allergic diseases has increased in the Western world over at least the past 50?years (1). An increasing trend in allergic diseases has been observed also in Southeast Asia (2). The profile of sensitization and the association with allergic diseases are different among areas of the world and reflect the allergen exposure. Worldwide, mites are the most common sensitizers (3, 4). Cockroach is another important sensitizer and its impact on disease may be increasing (3, 4). MI-773 cost Still few studies have investigated the prevalence, sensitization profile and risk factors for allergic sensitization in Southeast Asia, and no study has been performed in the northern part of Vietnam. We thus conducted a study with the aim to assess the prevalence of allergic sensitization and its association with find more asthma and rhinitis in northern Vietnam. The study was performed in two areas of northern Vietnam: urban Hoankiem, Hanoi, and rural Bavi 60?km west of central Hanoi. A sample of 1500 subjects aged 21�C70?years was randomly selected from all 5782 responders of a questionnaire survey conducted in 2007�C2008 (5). The subjects underwent a structured interview using a modified GA2LEN study questionnaire and skin prick test (SPT) with 10 common local allergens. SPTs were performed following the standards developed by the EAACI (6) using a lancet on the volar aspect of the forearm. A wheal size ��?3?mm was regarded positive. Definitions of asthma, rhinitis, symptoms and possible risk factors have been published previously (5). The study was approved by the Medical Ethics Research Committee of Hanoi Medical University and was performed from Otenabant March 2009 to April 2010. Data from the initial questionnaire survey (5) were used for evaluating the representativeness of the participants of the clinical study. PASW version 18.0 (Chicago, IL, USA) was used for statistical analysis. Difference in prevalence was calculated using chi-squared test, and a P-value