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5, P?=?0.002, 95% CI?=?2.1�C27.0). Neither age at recruitment, sex, nor years of education made significant contributions to the model, although women tended to be at greater risk (P?=?0.06). Recent evidence that D10S1423 resides within open reading frame C10orf112, whose predicted product resembles a low-density lipoprotein receptor, suggests a molecular mechanism for this gene�Cgene interaction. OTX015 chemical structure ? 2009 Wiley-Liss, Inc. ""The relative risk of immune-mediated disorders (IMDs) among women carriers of premutation alleles is estimated by a survey for IMDs among 344 carrier women (age 19�C81 years; mean 46.35 and SD 12.60) and 72 controls (age 18�C87 years; mean 52.40 and SD 15.40). One hundred fifty four (44.77%) women carrier had at least one IMD, as did 20 controls (27.78%). Among women carriers, autoimmune thyroid disorder was the most common (24.4%), then fibromyalgia (10.2%), irritable bowel syndrome (IBS; 9.9%), Raynaud's phenomenon (7.6%), rheumatoid arthritis (RA; 3.8%), Sj?gren syndrome (2.6%), systemic lupus erythematosus (SLE; 2.03%), multiple sclerosis (1.74%). Of 55 carriers age 40 or older with FXTAS, 72.73% had at least one IMD, compared to 46.54% of those without FXTAS (n?=?159), and 31.58% selleck kinase inhibitor of controls (n?=?57). The estimated odds ratio (OR) for IMD is 2.6 (95% CI 1.2�C5.6, P?=?0.015) for women with FXTAS relative to those without FXTAS; the likelihood of IMD in carriers without or with FXTAS was also Transducin significantly higher than for controls (OR 2.1, 95% CI 1.1�C4.2, P?=?0.034; OR 5.5, 95% CI 2.4�C12.5, P?