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We collected data on the use of disease-modifying medications (0 = no, 1 = yes) and symptomatic medications (0 = no, 1 = yes) using a standard laboratory questionnaire. The same questionnaire Obeticholic Acid nmr provided information on the clinical course of MS (0 = RRMS, 1 = progressive MS) based on definitions consistent with the Lublin and Reingold criteria.15 We collected data on disability status using the validated Patient-Determined Disease Steps (PDDS) scale,16 forming groups of mild (PDDS score ��2) and moderate (PDDS score of 3?6) disability (0 = mild, 1 = moderate) consistent with previous research.17 We collected data on height and weight using a scale stadiometer for computing body-mass index (BMI; calculated as weight Microbiology inhibitor in kilograms divided by height in meters squared) and formed groups of normal weight (BMI CDK9 such that new content became available seven times during the first 2 months, four times during the second 2 months, and twice during the final 2 months of the intervention. The behavioral intervention further involved weekly one-on-one behavioral coaching sessions via Skype technology (Skype Communications SARL, a division of Microsoft Corp, Luxembourg City, Luxembourg). The sessions were semi-scripted and based on principles of supportive accountability (ie, encouraging participants to wear the pedometer daily and monitor behavior change and goal attainment throughout the 6-month intervention).