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Fisher��s PLSD was used for statistical analysis, and a P-value of find more statistically significant. Results Vitreal tryptase activity in vitreoretinal diseases The 54 eyes of the 54 patients who underwent vitrectomy included 14 eyes of 14 MH patients (six males and eight females; mean age: 66.1��5.3 years), 14 eyes of 14 PDR patients (nine males and five females; mean age: 59.0��13.7 years), 13 eyes of 13 ERM patients (four males and nine females; mean age: 63.8��8.9 years), and 13 eyes of 13 RRD patients (ten males and three females; mean age: 53.8��7.5 years). All patient ages are expressed as mean �� standard deviation (SD). Vitreal tryptase activity (mean �� SD) in MH, PDR, ERM, and RRD was 0.0146��0.0053, GRB10 0.0018��0.0018, 0.0166��0.0046, and 0.0117��0.0029 mU/mg protein, respectively. Vitreal tryptase activity was significantly higher in MH and ERM than in PDR and RRD (PAG-490 mouse and the intravitreal tryptase levels. We also investigated the presence of posterior vitreous detachment (PVD) via the patients�� medical records. The results revealed PVD in five cases and no PVD in eight cases. Moreover, no relationships were found between the presence of PVD and the intravitreal tryptase levels. In addition, we carefully evaluated the severity of ERM by fundus photograph and OCT imaging. The results showed no relationships between the severity of ERM and the intra-vitreal tryptase levels. Anti-IIC IgG antibody measurement in the serum For the measurement of anti-IIC IgG antibody in the serum, blood samples were obtained from 46 patients, ie, 17 patients with ERM, eight patients with CAT, 12 patients with PDR, and nine patients with RRD. The serum levels of anti-IIC IgG antibody (mean �� SD) in ERM, CAT, PDR, and RRD were 58.222��30.986, 34.890��18.165, 55.760��26.008, and 35.453��12.769 units/mL, respectively. The serum levels of anti-IIC IgG antibody were significantly higher in ERM and PDR than in CAT and RRD (P