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The LOS was significantly higher in patients who developed SSIs in general and meningitis in particular (p?VAV2 were 2.79/1000 patient-days. The rate of meningitis was 1.13/1000 patient-days. The total fatality rate in the present cohort was 8.3% (5% for the patients that did not undergo neurosurgery and 12.8% for patients who did). The difference was statistically significant (OR, 2.8; CI, 1.65�C4.8). Development of SSIs was associated with increased adverse final outcomes (OR, 2.9 (1.3�C6.6); p?0.016). Meningitis was not associated with increased adverse final outcomes (OR, 2.42 (0.68�C8.66); p?0.16) Among the total number of infections encountered, ventilator-associated pneumonia (VAP) was the most common (33.2%), with surgical site infections (SSIs) (17%), urine tract infections (UTIs) (15.4%), pneumonia (14.0%), catheter-associated bacteraemias/blood stream infections (CAB/BSI) (10.7%) and meningitis following (7.9%). The infection rates, expressed in number/1000 patient-days were 4.71 VAP/1000 patient-days, Lonafarnib 2.2 UTI/1000 patient-days and 1.5 Tyrosine Kinase Inhibitor Library bacteraemias/1000 patient-days. The median duration of surgery was 2?h (range, 0.5�C4.5). In 23% of the patients there was insertion of some kind of drain and 14.8% had intraparenchymal Camino? intracranial pressure monitoring (ICP) (Camino Laboratories, San Diego, CA, USA) or a Codman MicroSensor? (Johnson and Johnson Medical Ltd, Raynham, MA, USA) catheter inserted. Several variables were examined for their contribution to the risk of SSI development, both superficial and deep-seated, including meningitis. TBI patients who underwent neurosurgery had an OR of 25.0 (95% CI, 3.3�C189.6) for developing meningitis compared with patients who did not. The median time between the surgery and the meningitis diagnosis was 7?days (range, 2�C41). Among the 194 cases with a drain, 13.4% developed an SSI and 6.7% developed meningitis. The risk of SSIs and meningitis increased by days of CSF drainage (Figs?1 and 2, respectively). A low admission Glasgow Coma Scale (GCS) score was significantly correlated with a longer length of stay (LOS) (p?
