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Figure 11a shows the mini-coil realized by winding a wire around a glass. This microtube is also used as a sample holder for NMR spectroscopy. This mini-coil was matched to a 50-�� coaxial cable connected to the spectrometer. A low complexity procedure was performed to match the impedance by changing the number of turns according to the siminmulation shown in Figure 11. These HFSS simulation results reveal quality factor properties. Thereafter, the experiments were perfromed on various chemical solutions as shown in Figure 12. As seen in these figures, the spectrum SB203580 supplier of water and toluene is very similar to the simulated ones. Additionaly, we tested the mini-Coil using acetone and hexane. Figure 11 Experimental NMR (a) mini-coil connected to probe and a probe (300 MHz, Bruker) and (b) quality factor simulation results of mini-coil with different number of turns. Figure 12 Mini-Coil Experimental results, Water, Toluene, Acetone and Hexane. 5. Discussion The development of a microhole inside CMOS based vertical coils is key toward realization of active NMR probes for drug discovery applications. Throughout this buy Fulvestrant paper, we discussed the vertical ��Coil and LNA and, in this section, the key post-processing factor is discussed. Indeed, the functionality of vertical coil depends on the fact that the sample is placed inside the coil. For this, the creation of micro-holes is crucial in this technique. Additionally, the development of high-throughput NMR spectroscopy should also be interfaced with a microfluidic structure in order to introduce the chemical samples to the NMR sensors. Post-Processing: The creation of micro-scale through-CMOS holes at the center of the vertical ?coils will be a technological leap that will bring us closer to the development of disposable Alizarin ?F devices and reusable CMOS 2D-NMR systems. As described by Uddin et al., electron-beam (e-beam) lithography can efficiently be used to drill tiny holes (Diameter