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99-year age group indicating a greater applicability of this method in these age groups. Graphical presentation of mean chronological age in various age intervals and its comparison with mean age obtained from Demirjian's method and Indian method are present in Figure 3. Table 4 Comparison among chronological age (CA), Demirjian's age (DA) and Indian age (IA) in females Figure 3 Graphical representation Epigenetics Compound Library of differences in dental ages obtained from different methods, compared to chronological age of study sample in females In statistics, the Mean absolute error (MAE) is a quantity used to measure how close predictions are to the eventual outcomes. It is the mean error irrespective of positive or negative sign. The effectiveness of two methods (Demirjian's and Indian) were compared in terms of mean absolute error that were either ��2 years. The Demirjian's formulas revealed better age prediction (MAE = 0.83 years) compared to Indian formulas (MAE = 1.81). Most of the observations in Demirjian's method were present with in age estimations were obtained from Demirjian's formulas than Indian formulas [Table 5]. Table 5 Mean absolute error obtained in Demirjian's and Indian methods Discussion The pattern of tooth development was reasonably consistent with minor variations between population of different ethnic origin and it was the rate of development that varied from region to region. For this reason Demirjian's method has been widely used throughout the world, and has been AR-42 research buy shown to provide an accurate estimate of age when modified to the local population. Most of these modifications have involved either changing the values of the self-weighted maturity scores and/or constructing regression models based on local samples. One such modification was done by Dr. Ashith B. Acharya in 2010. He tested Demirjian's 8teeth method using 547 Indians (348 females and 199 males) aged between 7 and 25 years and developed Indian-specific regression formulas. The kappa statistics for the present study indicated the level of intra-observer agreement to be ��substantial�� in males and ��almost perfect�� in females. In absolute terms the study reported an intra-observer agreement of 82.26% in males Inulin and 91.94% in females. Maia NCG et al., reported a mean intra-observer and inter-observer agreement of 86.6% (kappa value �C 0.67) in his study using Demirjian's method.[4] The predictive maturity scores and cubic regression formulas of this study are population specific. While they may work well on cases of French-Canadian origin they found to over- or under-estimate predicted age in population of a genetically different heritage. In the present study, the Demirjian's method under estimated dental age by 0.84 years in males and 0.83 years in females which were found to be statistically significant at P
