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[9] Hence, the present study was carried out with the aim to assess the Samavaya relation between Ama and its Hetu and Lakshanas along with Practical evaluation of Samavaya by using Pippalimula on Ama. Materials and Methods Patients having the classical signs and symptoms of ��Ama�� attaining the Out-Patient Department and In-Patient Department were selected without any bar of cast, religion, occupation and sex. The study was approved by Institutional Ethics Committee (No. PGT/7-A/Ethics/2010-11/1858; dated on 01/09/2010). Criteria for selection Patients suffering from the state of Ama Patients of age between 20 and 60 years. Criteria for exclusion Patients of age 60 years Patients having the condition of ��Samshrishta Dosha�� (chronic stage) Patients having any major systemic disease Patients having the dominancy of ��Pitta Florfenicol Prakriti��. Grouping and sampling Patients were randomly divided into two groups as: Group A: Tablets (500 mg each) of Pippalimula Churna (P. longum root powder) has CSF-1R inhibitor been provided Group B: Tablets (500 mg each) of rice flour (placebo) has been provided [Table 1]. Table 1 Drug and posology Investigations Routine pathological tests such as blood, urine, stool etc., has been carried out to assess the actual status of the patients and to rule out any pathology. Criteria for assessment The result was assessed on relief of the signs and symptoms of the disease.[10,11] The sign and symptoms were Aruchi (aversion), Avipaka (indigestion), Udaragaurava (heaviness of abdomen), Kshudhanasha (dyspepsia), Tandra (lassitude), Hrillasa (nausea), Alasya (idleness), Gurugatrata (heaviness in body), Bahumutrata (polyuria), Malasamata (sticky stool) and decrease in Abhyavaharana and Jarana Shakti (slowness of hunger and digestion). The patient's sign and symptoms were noticed before and After treatment with scoring pattern depending upon their severities.[12] Assessment of result Overall percentage of improvement of each patient was calculated by the formula Paired t-test was carried out at each symptom individually in both groups, whereas Src inhibitors cancer unpaired t-test was applied to study the comparative results of both groups at the level of P 0.05, Significant: P