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Figure ?Figure3B3B illustrates the arrangement of the PCs for one typical group, where the black circles indicate PCs that projected to the same cerebellar nuclear neuron and gray circles show the positions of the remaining PCs in the array. For each PC, all of its CS were classified according to the level of synchrony in the group at the time of their occurrence using a 1-ms time window. The spikelet-related (T window) variance was also measured for each CS (defined in Methods). CSs were distributed over a range of 4�C9 synchrony levels, depending on the PC. Although there was considerable scatter, a clear relationship between spikelet-related variance and synchrony could almost always be observed by plotting the average variance level as a function of synchrony within the group Ceftiofur (Figure ?(Figure3C,3C, red circles). To test the significance of the relationship between spikelet-related variance and synchrony, a scatterplot of these parameters was constructed from the CSs of each PC. Such plots showed a significant and positive correlation with synchrony for spikelet-related variance for 41/42 PCs (p see more of r-values is shown in Figure ?Figure3D3D (r = 0.26 �� 0.089, n = 42). Tests for linearity showed a good fit for most cells (MSSLOF/MSSPE; p > 0.05, n = 25/41 PCs). For the other PCs no dominant pattern to the deviation from linearity was found, with some cells showing supralinear increases at the highest synchrony levels, and some having curves that plateaued. Next, to look for evidence of field effects that might contribute to the variance signal, we measured the baseline variance in the millisecond just prior to the onset of the CS. If fields due to synchronized activity from nearby cells were contributing to the p53 inhibitor signal, they should be present in the milliseconds preceding the CSs in the recorded cell, because ��synchronized�� CSs occur over a time window that spans at least several milliseconds (see Discussion for details). Overall, the r values for the baseline (0.030 �� 0.062, n = 42) were much smaller than those for the T window. However, although the r value for the baseline was either not different from zero or negative for the majority of PCs (Figures 3C,D, black circles; p > 0.05, n = 20; r 0 and p

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