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A: The expression levels of ataxia telangiectasia mutated (ATM) and DNA dependent protein kinase (DNA-PKcs) in ... Up-regulated miR-210 expression reduces the size of the spheres formed by the stem-like cells The spheres that had the various cell types had developed in serum-free medium at 7 d after irradiation were compared (Figure ?(Figure5).5). The diameters of the cell spheres that pmiR-210 transfected TE-1R cells formed were smaller than those formed by Ctrl cells (0.60 �� 0.14, P formation of pmiR-210 cells after irradiation (bar: 100 ��m). PmiR-210: Transfected with pmiR-210; Ctrl: Transfected with a nonsense sequence; Untr: Untreated. Cell spheres were allowed to form in serum-free medium for Integrase inhibitor 7 d after 4-Gy ... DISCUSSION MiR-210 is highly expressed in glioma[13], melanoma[14,15], renal cell carcinoma[16], pancreatic cancer[17,18], breast cancer[19-21] and lung cancer[22] that are generally associated with a poor disease-free survival rate or poor overall survival rate. The up-regulation of miR-210 expression directly suppressed Bcl-2 adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) expression to maintain the survival of neural progenitor cells[4] and knocking down the expression of miR-210 PD184352 (CI-1040) in combination with radiotherapy was found to have enhanced its anti-tumour effect in human hepatoma xenografts[5]; and moreover, miR-210 expression promoted more efficient DSB repair[7]. click here Unexpectedly, the significantly lower expression of miR-210 in ESCC tissues was observed in paired tumour/normal tissue sets in our study. In this study, we observed a low level of miR-210 expression in 81.1% of the tumours of male ESCC patients than in the isogenically paired tissues (P