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Among NHW, the AD-GRS including APOE was associated with worse memory score for people aged 65+ but not people aged 50�C64 (P that the mean AD-GRS differed by age groups (age 50�C65 vs. 65+). The mean AD-GRS TAK-632 in both age groups was 0.09 for NHW and 0.12 for NHB. The APOE ��4 allele frequency was similar for NHW in each age group (0.29 for age 50�C65, 0.28 for age 65+). However, it differed slightly by age for NHB (0.45 for age 50�C65, 0.38 for age 65+). Finally, we estimated gender-stratified models to explore whether the association between the AD-GRS and either dementia or memory score differed by gender. Among NHW, there was no evidence for differential effects by gender for either dementia (P = 0.757 for interaction of AD-GRS and gender) or memory (P = 0.670 for interaction of AD-GRS http://www.selleckchem.com/products/gdc-0068.html and gender). Similarly, among NHB, the gender-by-AD-GRS interaction terms for dementia (P = 0.174) and memory (P = 0.304) were not statistically significant. Overall, we did not find any evidence for differences between males and females within either racial group. Conversely, estimates obtained using the AD-GRS excluding APOE found all groups to be similar except NHB males and females for the dementia probability outcome (P = 0.047 for interaction of AD-GRS excluding APOE and gender). Among NHB males, the AD-GRS excluding APOE was associated with an OR of 3.60 (95% CI: 1.62, 8.00; P Wnt inhibitor our findings suggest a difference in the relative effect of the AD-GRS on dementia probability and memory score by race, providing evidence against our original hypothesis. The AD-GRS including APOE had larger relative effects on dementia in NHW than in NHB, although absolute effects were similar. The AD-GRS also had significantly smaller relative effects on memory among NHB than NHW. However, a modified AD-GRS without APOE was associated with slightly larger effects on dementia probability for NHB than NHW.