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Both treatment groups were well tolerated. Budesonide/formoterol maintenance and reliever therapy provided more Oxacillin effective asthma control, including a prolonged time to first severe asthma exacerbation, than budesonide/formoterol plus terbutaline and was well tolerated. Budesonide/formoterol maintenance and reliever therapy also improved lung function and asthma symptoms. ""3771" "For further resources related to this article, please visit the WIREs website. ""3772" "RINAKO ISHIKAWA1, TETSUYA OKANO1, TOMOHIKO MIO1, AI MASUMOTO1, AKIKO KAWASHIMA1, YURI MAENO1, SUSUMU YAMAZAKI2, HISAYOSHI DAITO1, OU YAMAGUCHI1, YOSHITAKE MURAYAMA1, KOICHI HAGIWARA2, KUNIHIKO KOBAYASHI1 1Department of Respiratory Medicine, Saitama Medical University International Medical Center, Saitama, Japan, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan Background?Carcinomatous meningitis (CM) in non-small cell lung cancer (NSCLC) has no standard treatment, and is treated by almost always palliative care. The prognosis for patients LY2109761 molecular weight with carcinomatous meningitis is poor, with a median survival up to 2 months. Recently, it is found that there are subgroups with driver mutations in NSCLC, and epidermal growth factor receptor (EGFR) mutation is most frequent, and tyrosine kinase inhibitors (TKIs) are very active for EGFR-mutated tumors. Methods?Screening of EGFR mutations, which are tested by the PNA-LNA PCR Clamp, has started from 2007 in our institution. We performed a retrospective study investigating incidence, clinical course and survival of consecutive patients with CM in a single institution from April. 2007 to June. 2013. Results?During this period, 1677 NSCLC patients were tested by the PNA-LNA PCR Clamp, and there were 397 patients harboring EGFR mutations and 1280 patients without them. A total of 28 patients experienced CM (18 patients with EGFR mutations, 8 patients without them, and 2 patients without information of pathology and mutation status because of poor PS). Incidence of CM in patients with EGFR-mutations was significantly higher than that Histone Methyltransferase inhibitor in patients without EGFR mutations (4.5% vs. 0.6%, respectively, Fisher's exact test: p?