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?2; P?ALOX15 such as FoxO3a, SMP30, Tbx3 and p16INK4a. We believe that the relationships of ��-catenin and some senescence-related proteins and the exact mechanisms of ��-catenin in senescence might be a novel and potent way to study cellular senescence and skin aging. This study was supported by the grants from the National Natural Science Foundation of China (NO. 30800992), the Specialised Research Fund for the Doctoral Program of Higher Education (20100162110035), the Natural Science Foundation of Hunan Province (NO. 10JJ9018), the Scientific Research Fund of Hunan Provincial Science C59 wnt and Technology Department (NO. 2010FJ3155), the Science Foundation of China Dermatologist Association-P&G (NO. 2010CDA-P&G04) and the Key Scientific Research Foundation of Nanhua Hospital, University of South China (NO. 10nyz01). We thank Mr Randall Widelitz (University of Southern California, Los Angeles) for editing the manuscript. Li-ming Tian, Ting Yang and Yao-hua Hu performed the research. Li-ming Tian, Hong-fu Xie and Ji Li designed the research study. Xiao Xiao, Wei-zhen Wang and Lei-shan Liu contributed essential reagents or tools. Li-ming Tian, Xiang Chen and Ji Li analysed the data and wrote the article. Hong-fu Xie and Ji Li provided the grant. All authors have no conflicts of interest. Figure S1. ��-catenin expression level in NHSFs after H2O2 treatment. Figure S2. Identification of ��-catenin expression in transfected NHSFs. Figure click here S3. Effect of ��-catenin overexpression on intracellular ROS in NHSFs after H2O2 treatment. Table S1. The primer sequence and size of PCR products of target genes. ""Naevus spilus (NS) is a naevoid disorder characterized by hyperpigmented macules or papules scattered over a caf��-au-lait macule. Such caf��-au-lait macules are often present at birth, and the darker pigmented speckles of NS slowly increase in number and size over a period of several years. NS can therefore be difficult to evaluate clinically for the development of melanoma. In vivo confocal microscopy (IVCM) is a novel method that allows examination at cellular resolution of cutaneous lesions in vivo. IVCM has been shown to have twice the specificity of dermoscopy for the diagnosis of melanoma, with comparable sensitivity. It has been shown to be useful in the detection and grading of dysplastic naevi, which are recognized precursors of melanoma in some cases.