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Interactions of these covariates were explored. TG and TSH were log-transformed to improve the fit of the linear regression models. Statistical significance level was assigned for P Torin 1 manufacturer and 2961 (57.5%) females, with a mean age of 39.71 �� 14.2 years (ranged 20 - 90 years); the prevalence of hypothyroidism was as follows: subclinical hypothyroidism 5.6% and hypothyroidism 1.9%. Demographics, anthropometrics and hormonal profile of patients with subclinical hypothyroidism, overt hypothyroidism and euthyroid controls are shown in Table 1. Table 1. Demographic, Anthropometrics and Hormonal Profiles of Patients With Subclinical and Overt Hypothyroidism and Euthyroid Controls a,b A total of 39 subjects with subclinical hypothyroidism had TSH levels more than 10 mU/L and 39 patients with overt hypothyroidism had TSH levels below 10 mU/L. In 288 subjects with SCH, 140 (48.6%) had positive results for thyroid antibodies. In 100 subjects with overt hypothyroidism, 72 had positive titers. Total cholesterol level was significantly higher in overt hypothyroidism in comparison to subclinical hypothyroidism (P = 0.003). BMI, weight and serum levels of LDL cholesterol and TG were significantly higher in overt hypothyroidism in comparison to subclinical hypothyroidism. Mean �� SD of HDL level was 37.6 �� 9.1 and Hesperadin 44.7 �� 11.1 mg/dL in men and women, respectively. There was a weak correlation between serum TSH and HDL levels in both male (r = -0.04 PABT-737 triglycerides (r = 0.2, P = 0.00), SBP (r = 0.5, P = 0.00), DBP (r = 0.3, P = 0.00) but not with HDL-C. In total population, there were no significant correlations between serum TSH levels and age, BMI, WC, W/H ratio or between TSH and total cholesterol, LDL-C, HDL-C and triglycerides. There was a relatively weak negative correlation between TSH and TG/HDL (r = -0.02, P = 0.04). There were no correlations between TSH and lipid profiles in individuals with subclinical hypothyroid, but there was a weak negative correlation between serum concentrations of FT4 and LDL-C, triglycerides, total cholesterol and HDL-C (Table 2 in the supplementary appendix, available with the full text of this article at www.endometabol.com). In normal population, we found evidence of interaction between TSH levels and smoking for serum levels of HDL-C and TG.

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