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02). After correction, significant relationship of MMP-9 gene expression and tumor differentiation grade was found only between groups with G1 and G3 tumors (p=0.007) (G1 vs G2 p=0.02; G2 vs G3 p=0.22)._No significant correlation was found among MMP-9 gene expression in blood as well as in tumor tissue and pathological stage, lymph node status, receptor status ( Tab. 5). Genotyping of the MMP-9 -1562 polymorphism was performed in all breast cancer patients' samples. The CC, CT and TT genotypes of MMP-9 gene were observed in 39 (44.3%), 38 (43.2%) and 11 (12.5%) of the breast cancer cases, respectively. The distributions among genotypes regarding clinicopathological parameters are shown in Tab. 6. Significant differences in the distribution among genotypes and pathological stage as well as lymph node status were found (p=0.02 and p=0.002, respectively). After Bonferroni PTPRJ correction, significant Protein Tyrosine Kinase inhibitor differences in the distribution among genotypes were found between groups with stage I and stages III/IV (p=0.005) as well as between groups with lymph node status N0 and N1 (pDasatinib in blood and showed shorter survival time (p=0.04) (Fig. 4), while the regression analysis according to a Cox proportional hazards model didn't demonstrate that positive MMP-9 gene expression could be associated with low survival rate (p=0.07, HR=0.14, 95% CI 0.01�C1.24). Positive MMP-9 expression was detected in 81 breast tumor samples from 87 samples. Overall survival analysis for the patients didn't show significant differences in survival rate among negative and positive MMP-9 expression in tumor and selected clinicopathological parameters.