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Induction immunosuppression therapy included quadruple therapy with antithymocyte globulin (ATG) induction (1.5?mg/kg/day; range, 6�C12?days), tacrolimus azathioprine or mycophenolate mofetil, and steroids. Those patients with allergic reactions to ATG received basiliximab. Acute rejection episodes were treated with steroid pulses. Donor duodenal patches were irrigated with a solution including cefalotin and amphotericin B or fluconazole, as previously described [3]. All patients received perioperative antibacterial prophylaxis with vancomicin and ceftazidime for 3?days after transplantation and thereafter ciprofloxacin and fluconazole 100 mg/daily until discharge or for a maximum of 42?days [7]. Cotrimoxazole (800/160?mg) Epigenetic pathway inhibitors thrice weekly during the first 6?months was used in prophylaxis against Pneumocystis jirovecii. CMV prophylaxis changed over time. All patients received intravenous ganciclovir (5?mg/kg/24 IV, adjusted to renal function) while they were receiving ATG. Additionally, CMV-seropositive recipients received one of the following regimens: (i) no additional prophylaxis (from 1995 to April 1999); (ii) universal prophylaxis with oral ganciclovir or valganciclovir, adjusted to renal function Mianserin HCl for the first 12?weeks after transplantation (from May 1999 to September 2008, except from September 2002 to December 2004); or (iii) preemptive therapy (PT) guided by weekly pp65 antigenaemia (from September 2002 to December 2004). CMV-seronegative recipients who received a graft from a seropositive donor received prophylaxis with ganciclovir or valganciclovir during the first 12?weeks after transplantation [10]. Severe infections were defined as those that needed systemic antibiotic therapy and required at least 24?hours of hospital admission. Centers for Disease Control and Prevention (CDC)/National Healthcare Safety Alectinib Network (NHSN) criteria for infection definitions were used [11]. Asymptomatic bacteriuria and asymptomatic episodes of CMV viraemia were specifically excluded from the analysis. CMV disease required the presence of clinical symptoms with the demonstration of virus by means of virological or pathological methods [12]. A vascular surgeon, by means of Doppler studies, arteriography or computed tomography-guided angiography before transplantation, diagnosed peripheral artery disease. Severe pancreatic graft dysfunction was defined as the need for permanent insulin therapy at the end of the follow-up. Categorical variables were expressed as absolute and relative frequencies. Quantitative variables were expressed as the mean and standard deviation (SD) or median and interquartile range (IQR). Differences between means were analysed using Student��s t-test or the Mann�CWhitney U-test as appropriate. Categorical variables were compared using the chi-squared test or Fisher��s exact test. Crude and adjusted odds ratios (ORs) were calculated by logistic regression. Those variables with a statistical significance Wald p?
