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MCI patients had more prior strokes than dementia patients (37 vs. 26%). When ischemic lesions were examined according to Hachinski ischemic scale, VaD had the highest score (6 �� 5 total score). Parkinsonism Features The presence of extrapyramidal signs (EPS) was measured with UPDRS III (motor subscale) test. In our sample, 17 patients presented with EPS, corresponding Amiloride to all patients with PDD and DLB. UPDRS III scores were higher in PDD than in MCI (mean values of 37 vs. 9 in a 0�C108 scale). Cognitive Test Function and Neuropsychological Battery Our population of probable dementia patients did not show significant differences regarding MMSE scores among dementia subtypes (mean MMSE score for probable dementia and MCI was 21 and 25, respectively). A significant association was found between dementia and the global neuropsychological function, measured as a summary of the different affected areas (p = 0.025). When we analyzed each neuropsychological area separately, patients with overall dementia (regardless of dementia subtype) had a higher frequency of affectation of the orientation domain compared to those with MCI (35% in MCI and 58% in dementia, p selleck chemical dementia (16% in MCI and 39% in dementia, p Vemurafenib clinical trial significant association regarding frontal, basal ganglia, infratentorial and Wahlund Scores with vascular component according to FRS (p